COA of Formula: C10H12O2. Recently I am researching about POSITRON-EMISSION-TOMOGRAPHY; CARBOXYLIC-ACIDS; MERGING PHOTOREDOX; H BONDS; FLUORINE; NICKEL; DEOXYFLUORINATION; CARBOFLUORINATION; CATALYSIS; DERIVATIVES, Saw an article supported by the National University of Singapore President’s Assistant Professorship start-up grant [R-143-000-A50-133]; NSFNational Science Foundation (NSF) [CAREER 1751568]; University of Maryland College Park; XSEDE [CHE160082, CHE160053]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Wang, HY; Liu, CF; Song, ZH; Yuan, MB; Ho, YA; Gutierrez, O; Koh, MJ. The CAS is 103-25-3. Through research, I have a further understanding and discovery of Methyl 3-phenylpropionate
Fluorine-containing organic molecules, particularly those that bear (sp(3))C-F bonds, are rapidly gaining prominence in modern chemical synthesis. Although extensive studies have been devoted to the preparation of secondary and tertiary fluorides, crucial shortcomings remain: for example, lengthy substrate synthesis, contrived installation of difficult-to-remove directing/activating units, excessive waste generation and/or limited functional group compatibility. Here, we show that readily accessible alpha-onofluoro carboxylic acids, which are conventionally difficult substrates for cross-coupling, undergo direct decarboxylative crosscoupling with sp(2-) and sp(3-)hybridized organohalides to afford a wide assortment of fluorinated products. Reactions are typically promoted by a combination of 1 mol % of an Ir-based photocatalyst and 2-15 mol % of a bipyridine-Ni complex, delivering products in up to 86% yield under blue LED light irradiation. Concise synthesis of key therapeutic candidates underscores utility, complementarity, and distinct advantages compared with existing methods. DFT calculations are used to rationalize the distinct reactivity of alpha-fluoro carboxylic acid substrates (vs nonfluorinated parent acids) under decarboxylation conditions.
COA of Formula: C10H12O2. About Methyl 3-phenylpropionate, If you have any questions, you can contact Wang, HY; Liu, CF; Song, ZH; Yuan, MB; Ho, YA; Gutierrez, O; Koh, MJ or concate me.
Reference:
Patent; SANOFI; US2011/294788; (2011); A1;,
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