Application In Synthesis of Methyl 3-phenyl-2-propenoate. Recently I am researching about FAST-ATOM-BOMBARDMENT; BIGINELLI; 3-AMINO-1,2,4-TRIAZOLE; ANTICANCER, Saw an article supported by the Ministry of Education and Science of Ukraine [0118U002025]; V. N. Karazin Kharkiv National University [811H/10-18, 811H/6-19]. Published in TAYLOR & FRANCIS INC in PHILADELPHIA ,Authors: Shvets, EH; Pidvorotnia, AV; Kulyk, OG; Mazepa, AV; Kolosov, MA. The CAS is 103-26-4. Through research, I have a further understanding and discovery of Methyl 3-phenyl-2-propenoate
4,7-Dihydroazolo[1,5-a]pyrimidin-5-ylmethanesulfonamides are side-products of the three-component Biginelli-like reaction of aminoazoles, aldehydes andN,N-dialkyl-2-ketomethanesulfonamides. Herein, we report a straightforward synthesis of 5-sulfonamidomethyl substituted 4,7-dihydroazolo[1,5-a]pyrimidines by a two-component condensation of aminoazoles andN,N-dialkyl(cinnamoyl)methanesulfonamides in DMF at reflux. The startingN,N-dialkyl-2-ketomethanesulfonamides can be obtained by either lithiation ofN,N-dialkylmethanesulfonamides and reaction with aldehydes followed by oxidation of the resulting alcohols or by Claisen condensation ofN,N-dialkylmethanesulfonamides with the corresponding esters. The chemical structures of all synthesized compounds are supported by(1)H and(13)C NMR-spectroscopy, mass spectrometry and elemental analysis.
Application In Synthesis of Methyl 3-phenyl-2-propenoate. About Methyl 3-phenyl-2-propenoate, If you have any questions, you can contact Shvets, EH; Pidvorotnia, AV; Kulyk, OG; Mazepa, AV; Kolosov, MA or concate me.
Reference:
Article; Weng, Shiue-Shien; Ke, Chih-Shueh; Chen, Fong-Kuang; Lyu, You-Fu; Lin, Guan-Ying; Tetrahedron; vol. 67; 9; (2011); p. 1640 – 1648;,
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