Safety of Methyl 3-phenyl-2-propenoate. Recently I am researching about BAYLIS-HILLMAN REACTION; BIO-BASED SOLVENTS; GAMMA-VALEROLACTONE; PROPYLENE CARBONATE; HECK REACTION; DIHYDROLEVOGLUCOSENONE CYRENE; MECHANISM; CHALLENGES; REACTIVITY; CATALYST, Saw an article supported by the Thailand Research FundThailand Research Fund (TRF) [RSA6280031]; Khon Kaen University; Center of Excellence for Innovation in Chemistry (PERCH-CIC), Ministry of Higher Education, Science, Research and Innovation; Institute for the Promotion of Teaching Science and Technology for the Development and Promotion of Science and Technology Talents Project scholarship. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Sangon, S; Supanchaiyamat, N; Sherwood, J; McElroy, CR; Hunt, AJ. The CAS is 103-26-4. Through research, I have a further understanding and discovery of Methyl 3-phenyl-2-propenoate
There is a lot of interest in the development of new, safer and more sustainable polar aprotic solvents due to their importance in industrial applications and significant safety issues with the most commonly used examples. One such area of application is in pharmaceutically relevant C-C coupling reactions, where polar aprotic solvents are commonly used for solubility and to stabilise reaction intermediates. Although there are now a number of excellent alternatives in the literature, to date they have not been compared in a single study. This study demonstrates the effectiveness of the green solventsN-butylpyrrolidinone (NBP), gamma-valerolactone (GVL), propylene carbonate (PC) and dihydrolevoglucosenone (Cyrene) in Heck and Baylis-Hillman reactions. Good conversions and initial rates were observed in GVL and NBP in Heck reactions. Cyrene exhibited high initial rates of reaction and high yields in the Baylis-Hillman reaction. This demonstrates Cyrene to be a promising alternative polar aprotic solvent for this reaction.
Safety of Methyl 3-phenyl-2-propenoate. About Methyl 3-phenyl-2-propenoate, If you have any questions, you can contact Sangon, S; Supanchaiyamat, N; Sherwood, J; McElroy, CR; Hunt, AJ or concate me.
Reference:
Article; Weng, Shiue-Shien; Ke, Chih-Shueh; Chen, Fong-Kuang; Lyu, You-Fu; Lin, Guan-Ying; Tetrahedron; vol. 67; 9; (2011); p. 1640 – 1648;,
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