In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 7270-63-5, name is 5-Diazo-2,2-dimethyl-1,3-dioxane-4,6-dione belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Formula: C6H6N2O4
General procedure: Rh/Au catalyzed (but-3-yn-1-yl)-aniline trapping with diazos: To a 4.0 mL vial equipped with a magnetic stir bar was added Rh2(esp)2 (1 mol %), PPh3AuCl (10 mol %), and AgSbF6 (10 mol %) directly into the reaction vessel. A solution of (but-3-yn-1-yl)-aniline (1.1 equiv.) was then added. Lastly, the diazo (1.0 equiv.) was added. The reaction vessel was sealed and allowed to stir at reflux for 16 h (Take caution when opening reaction flask. Evolution of N2 gas creates pressurized system.) After this time, the crude reaction mixture was filtered through a slurry of celite/silica gel, concentrated, and analyzed via crude 1H NMR. The crude mixture was then purified via flash chromatography to furnish functionalized spiropyrrolidines.
The synthetic route of 7270-63-5 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Hunter, Arianne C.; Almutwalli, Bilal; Bain, Anae I.; Sharma, Indrajeet; Tetrahedron; vol. 74; 38; (2018); p. 5451 – 5457;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics