In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 57486-67-6 as follows. Safety of Methyl 2-(2-fluorophenyl)acetate
Example 1A Methyl 3-(3,5-dichloropyridin-2-yl)-2-(2-fluorophenyl)-3-oxopropanoate 28.5 ml (28.5 mmol) of a 1 M solution of LiHMDS in hexane are added to 50 ml of THF at -78 C. A solution of 4.00 g (23.8 mmol) of methyl (2-fluorophenyl)acetate in 10 ml of THF is then added dropwise. The mixture is stirred at -78 C. for 1 h and then 6.00 g (28.5 mmol) of 3,5-dichloro-pyridine-2-carbonyl chloride are added in portions. After a further hour, the mixture is allowed to reach RT and saturated ammonium chloride solution is added dropwise. The mixture is diluted with water and extracted with ethyl acetate. The organic phase is washed with saturated sodium chloride solution and dried over sodium sulfate. The residue after concentration in vacuo is purified by chromatography on silica gel (eluent: dichloromethane/methanol 50:1). 4.46 g (46% of theory) of the desired compound are obtained as a yellowish oil. LC/MS (Method 5): Rt=2.77, 2.82 min; MS (ESIpos): m/z=340 (35Cl2), 342 (35Cl37Cl), 344 (37Cl2) [M+H]+.
According to the analysis of related databases, 57486-67-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Bayer Schering Pharma Aktiengesellschaft; US2010/29653; (2010); A1;,
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