Synthetic Route of 924-99-2,Some common heterocyclic compound, 924-99-2, name is Ethyl 3-(dimethylamino)acrylate, molecular formula is C7H13NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: The substituted benzoyl chloride (18.1 mmol), 3-(N,N-dimethylamino)acrylic acid ethyl ester (18.1 mmol), triethylamine (27.1 mmol) was dissolved in 30 mL of toluene, stirred at 90 C for 4 h, concentrated and column chromatographed to give Intermediate 1. ethyl 2-(2,4-difluorobenzoyl)-3-(dimethylamino)acrylate (R2=H): yield 65%
The synthetic route of 924-99-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Fudan University; Chen, Fen Er; He, Qiuqin; Mao, Tianqi; Wan, Zhengyong; (17 pag.)CN103965163; (2016); B;,
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