Synthetic Route of 924-99-2,Some common heterocyclic compound, 924-99-2, name is Ethyl 3-(dimethylamino)acrylate, molecular formula is C7H13NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
The compound 2,4-difluorobenzoic acid (950 mg, 6 mmol) was dissolved in 2 ml of thionyl chloride,Heated to 80 C reflux2 hours,After completion of the reaction, the solvent was dried to give an oily compound,The oily compound was placed on an oil pump for half an hour,Immediately put the next step.The compound of the previous step was quickly dissolved in dry toluene,And ethyl 3- (dimethylamino) acrylate (1 g, 7 mmol) was added,Triethylamine (1.01 g, 10 mmol)Heated to 90 C,Fully stirred for 12h,Cooled to room temperature, spin dry solvent, dissolved in ethyl acetate and washed several times with water,After concentration, the compound 1a (1.42 g, 85%) was obtained as a yellow oil by column chromatography elution (petroleum ether: ethyl acetate = 10: 1 to 2: 1).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Ethyl 3-(dimethylamino)acrylate, its application will become more common.
Reference:
Patent; Chinese Academy Of Sciences Shanghai Pharmaceutical Institute; Long Yaqiu; Geng Meiyu; Li Bowen; Ai Jing; Xu Zhongliang; (65 pag.)CN107151240; (2017); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics