Adding a certain compound to certain chemical reactions, such as: 924-99-2, name is Ethyl 3-(dimethylamino)acrylate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 924-99-2, Product Details of 924-99-2
[1311] to a solution of ethyl 3-(dimethylamino)acrylate (165 mg, 1.2 mmol) and tea (233 mg, 2.3 mmol) in THF (15 ml) was added a solution of compound 277b (400 mg, 2.3 mmol) in THF (5 ml) drop-wise over 30 mins. The mixture was stirred at 20 C for 12 hours. The reaction mixture was concentrated under reduced pressure to give a residue. The residue was purified by preparatory-tlc (SiO2, petroleum ether: ethyl acetate = 1: 1) to give compound 277c (240 mg, yield: 44.4%) as a pale yellow oil. 1H NMR (400mhz, CDCl3) delta 8.94 (s, 1h), 7.51 – 7.36 (m, 2h), 7.21 – 7.14 (m, 1h), 7.13- 7.04 (m, 1h), 4.17 (q, 7 = 7.1 hz, 2h), 1.15 (t, 7 = 7.2 hz, 3h).
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Reference:
Patent; BLADE THERAPEUTICS, INC.; BUCKMAN, Brad, Owen; YUAN, Shendong; ADLER, Marc; EMAYAN, Kumaraswamy; MA, Jingyuang; (687 pag.)WO2018/64119; (2018); A1;,
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