Adding a certain compound to certain chemical reactions, such as: 55666-43-8, name is tert-Butyl 3-bromopropanoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 55666-43-8, Recommanded Product: tert-Butyl 3-bromopropanoate
Cyclohexanecarboxylic acid (2.89 g, 22.6 mmol) was dissolved in THF (30 mL) and this solution added to a lithium diisopropylamide solution cooled to -15 C. (2M in THF/n-heptane/ethylbenzene, Aldrich) 24.3 mL (48.6 mmol) at such a rate as to keep the temperature below 0 C. The reaction mixture was then stirred at 0 C. for 2.5 hours before re-cooling to -15 C. and the addition of tert-butyl 3-bromopropionate (5 g, 23.9 mmol) in THF (50 mL) at such a rate as to keep the temperature below 0 C. The reaction mixture was allowed to reach room temperature and stirred overnight, before the reaction mixture was quenched by the addition of 2M HCl and extracted with ethyl. acetate 2×200 mL. The combined organic layers were dried (MgSO4) and then evaporated to an orange oil. Purification by flash chromatography [SiO2; dichloromethane/methanol/0.880 NH3 (97:3:0.5)] afforded the title compound as a gummy oil (800 mg, 14%). 1H NMR (CDCl3, 400 MHz), deltaH: 2.22 (2H, m), 2.07-2.00 (2H, m), 1.86 (2H, m), 1.45-1.16 (8H,m), 1.41 (9H, s): m/z (ES+) 279(MNa+); m/z (ES-) 255 M-H+)
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, tert-Butyl 3-bromopropanoate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Pfizer Inc; US2004/180941; (2004); A1;,
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