Adding a certain compound to certain chemical reactions, such as: 79669-50-4, name is methyl 5-bromo-2-methyl-benzoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 79669-50-4, Product Details of 79669-50-4
90. To a solution of methyl 5-bromo-2-methylbenzoate (1.5g, 6.548 mmol) in CCL (35 mL) was added NBS (1.4g, 7.86 mmol) followed by AIBN (65 mg, 0.393 mmol). The reaction mixture was heated at reflux for 6h. After reaction finished, the reaction mixture was poured into water and extracted with dichloromethane (50 mL x 3). The combined organic layers were dried with Na2SO4, filtered, concentrated. The residue was purified by chromatography (silica gel, hexane/EtOAc = 1 00/0 – 20/80) to give methyl 5-bromo-2- (bromomethyl)benzoate (1.513g, 75%).
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Reference:
Patent; GERO DISCOVERY LIMITED LIABILITY COMPANY; FEDICHEV, Petr Olegovich; GREENMAN, Kevin; CHIH-TSUNG, Chang; KHOLIN, Maksim Nikolaevich; GETMANTSEV, Evgeny Gennadievich; ZHIDKOVA, Tatiana Vladimirovna; KADUSHKIN, Alexandr Viktorovich; PYRKOV, Timofei Vladimirovich; SHISHOV, Dmitry Veniaminovich; BOLANOS-HERNANDEZ, Juan Pedro; ZAKURDAEVA, Kristina Aleksandrovna; BURMISTROVA, Olga Andreevna; (573 pag.)WO2020/80979; (2020); A1;,
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