Application of 1128-00-3,Some common heterocyclic compound, 1128-00-3, name is Ethyl 2-aminocyclohex-1-enecarboxylate, molecular formula is C9H15NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: To a solution of appropriate carboxylic acid 44a-d (1.0 mmol) in dichloromethane (6 ml) oxalylchloride (3.0 mmol) and a drop of DMF were added. The reaction mixture was stirred at ambient temperature for 40 min and the solvent was removed in vacuo. The residue was dissolved in dichloromethane (6 ml), and under argon to the obtained solution was added a mixture of ethyl 2-aminocyclohex-1-enecarboxylate (33) (1.1 mmol) and triethylamine (1.1 mmol) in dichloromethane (3 ml). The reaction mixture was stirred at room temperature for 2 h. The mixture was diluted with dichloromethane, washed successively with NaHCO3 solution, brine, and dried (Na2SO4). The solvent was removed and the residue was purified as indicated below to give crystalline compounds 45a-d.
The synthetic route of 1128-00-3 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Bobileva, Olga; Bokaldere, Rasma; Gailite, Vija; Kaula, Ilze; Ikaunieks, Martins; Duburs, Gunars; Petrovska, Ramona; Mandrika, Ilona; Klovins, Janis; Loza, Einars; Bioorganic and Medicinal Chemistry; vol. 22; 14; (2014); p. 3654 – 3669;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics