Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 35179-98-7, name is Chloromethyl ethyl carbonate, A new synthetic method of this compound is introduced below., Quality Control of Chloromethyl ethyl carbonate
Example 59: 4-{(R)-3-[Bis-(ethoxycarbonyloxymethoxy)-phosphoryl]-2-[(2-pheiiyl- thiazole^-carbony^-aminoj-propionylj-piperaziiie-l-carboxylic acid butyl ester A solution of Example 9 (100 mg) and NEt3 (0.08 mL) in DMPU (0.35 mL) was stirred for 10 min at RT. Then, NaI (35 mg) and carbonic acid chloromethyl ester ethyl ester (0.76 mg, prepared as described in WO2004092189) were added. The mixture was stirred overnight at 500C under argon. The reaction mixture was washed with H2O and the aq. phase extracted with toluene (3x). The combined org. phases were dried over Na2Stheta4 and concentrated to dryness. CC purification (EA/[CH2Cl2/Me0H 8:2] 1:0 to 3:1) gave 55 mg of the desired product. LC-MS: tR = 1.07 min; [M+H]+: 729.28.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; ACTELION PHARMACEUTICALS LTD; CAROFF, Eva; HILPERT, Kurt; HUBLER, Francis; LEHMANN, David; MEYER, Emmanuel; RENNEBERG, Dorte; WO2010/122504; (2010); A1;,
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