Synthetic Route of 2905-65-9,Some common heterocyclic compound, 2905-65-9, name is Methyl 3-chlorobenzoate, molecular formula is C8H7ClO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: The following experimental procedure for the partial reduction of ethyl benzoate to benzaldehyde is representative. A dry and argon-flushed flask, equipped with a magnetic stirring bar and a septum, was charged with ethyl benzoate (0.07 mL, 0.5 mmol) and THF (5 mL). After cooling to 0 C, cis-2,6-dimethylmorpholine-modified Red-Al (2.5 mL, 0.4 M 1.0 mmol) was added dropwise and the mixture was stirred for 30 min at the room temperature. The reaction was stopped aqueous 1 N HCl (5 mL) and the product was extracted with diethyl ether (10 mL). The ether layer was dried over anhydrous magnesium sulfate. GC analysis showed a 98% yield of benzaldehyde. All products in Table 1 were confirmed through comparison with GC data of authentic sample.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 3-chlorobenzoate, its application will become more common.
Reference:
Article; Shin, Won Kyu; Kang, Daehoon; An, Duk Keun; Bulletin of the Korean Chemical Society; vol. 35; 7; (2014); p. 2169 – 2171;,
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