Electric Literature of 721-63-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 721-63-1 as follows.
General procedure: Arylacetate(0.05mol) was dissolved in dry THF or toluene, and stirred in the ice bath.Sodium (0.075mol) was added to the solution, the mixture was stirred for 30 minin the ice bath. Ethyl formate (0.1mol) was added by dropwise to the above solution,the temperature of the reaction mixture was maintained at < 5 C.After the addition, the reaction mixture was stirred for another 2 h, thenwarmed to room temperature and stirred overnight (about 15 h). Water (50mL) wasadded to the slurry mixture, and stirred for an additional 30 min, thenportioned between organic layer and water. Water layer was extracted withdichloromethane (2×50mL). These extracts were discarded. The aqueous phase wasacidified with acetic acid or 5% hydrochloric acid, and extracted withdichloromethane (3×50mL). This extract was washed with water and brine, driedover anhydrous sodium sulfate, and the solvent was removed by rotaryevaporation under reduced pressure to give thick yellow oil, which was purifiedby column chromatography with ethyl acetate in petroleum ether.
According to the analysis of related databases, 721-63-1, the application of this compound in the production field has become more and more popular.
Reference:
Article; Liu, Jinbing; Chen, Changhong; Wu, Fengyan; Tang, Junyuan; Bioorganic and Medicinal Chemistry Letters; vol. 26; 7; (2016); p. 1715 – 1719;,
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