Synthetic Route of 50413-30-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 50413-30-4 as follows.
a) 4-((3,4-Difluorophenyl) amino) -7-fluoro-1H-indole-2-carboxylic acid ethyl ester 4-Bromo-7-fluoro-1H-indole-2-carboxylic acid ethyl ester (200 mg, 0.7 mmol) was dissolved in toluene (15 mL), and Pd2 (dba) 3 (64 mg, 0.07 mmol) and Davephos (55 mg) were sequentially added. , 0.14 mmol) and K3PO4 (446 mg, 2.1 mmol, 2.1 mL of H2O). After stirring well, a solution of 3,4-difluoroaniline (271 mg, 2.1 mmol) in toluene (4 mL) was added, and the reaction was refluxed for 20 h under the protection of argon. Cool to room temperature, concentrate, add EA (30mL) to dissolve the residue, 5N hydrochloric acid (10mL × 2), saturated brine (20mL × 2), water (20mL × 2) extraction, column chromatography (P / E = 5: 1) 177 mg of white solid was obtained with a yield of 75.7% and melting point: 195-197 C.
According to the analysis of related databases, 50413-30-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Chinese Academy Of Medical Sciences Pharmaceutical Institute; Xu Boling; Chen Xiaoguang; Cui Guonan; Lai Fangfang; Zhou Jie; Ji Ming; Wang Xiaoyu; Du Tingting; Li Ling; Jin Jing; (144 pag.)CN110483366; (2019); A;,
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