Electric Literature of 587-47-3,Some common heterocyclic compound, 587-47-3, name is Ethyl 2-(3-fluorophenyl)acetate, molecular formula is C10H11FO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A solution of ethyl 2-(3-fluorophenyl)acetate (18) (10.1 g, 55.0 mmol) inCCl4 (250 mL), is added with NBS (9.70 g, 55.0 mmol) and the mixture refluxed for 2 h at 800C (LC-MS monitoring: complete conversion). The solvent is evaporated and the resulting crude is dissolved in DCM and purified by filtration on a silica bed to obtain 7.80 g of (19) as a colorless oil (54% yield).
The synthetic route of 587-47-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; CHIESI FARMACEUTICI S.P.A.; CALIGIURI, Antonio; RICCABONI, Mauro; AMARI, Gabriele; WO2010/72338; (2010); A1;,
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