In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 23426-63-3 as follows. Application In Synthesis of Methyl 2-bromo-2-methylpropanoate
To a solution of 2,3,5-trimethylphenol (20.0 g, 147 mmol) in dimethylsulfoxide (100 ml) was added methyl 2-bromoisobutyrate (52.2 g, 288 mmol) and potassium carbonate (40.0 g, 289 mmol) at room temperature. The mixture was stirred for 36 hours. The resulting mixture was poured into water and extracted with ethyl acetate. The organic extract was washed with water and saturated aqueous sodium chloride, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was purified using basic silica gel column chromatography (hexane/ethyl acetate = 50/1) to obtain 30.3 g (yield 87 %) of oily title compound.1H-NMR (CDCl3) delta : 1.57 (6H, s), 2.11 (3H, s), 2.21 (6H, s), 3.79 (3H, s), 6.33 (1H, s), 6.46 (1H, s).
According to the analysis of related databases, 23426-63-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Takeda Chemical Industries, Ltd.; EP1411052; (2004); A1;,
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