Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 55666-43-8, name is tert-Butyl 3-bromopropanoate, A new synthetic method of this compound is introduced below., Safety of tert-Butyl 3-bromopropanoate
NaH (25.1 mg, 60%, 0.63 mmol) and then tert-butyl 3-bromopropanoate (69.7 uL, 0.42 mmoL) was added to 5-morpholino-3-(quinolin-3-yl)pyrazolo[l,5-a]pyrimidin-7- amine (72.3 mg, 0.21 mmoL) in DMF (3 mL). The mixture was stirred at room temperature until LCMS indicated complete conversion. The reaction mixture was diluted with Sat. NH4C1 and then extracted with ethyl acetate (x2). The combined organic layers were washed with brine and dried with Na2SC»4. Evaporation of solvent afforded the crude tert-butyl 3-(5- morpholino-3-(quinoIin-3-yl)pyrazolo[l,5-a]pyrimidin-7-ylamino)propanoate. The crude ester was heated with 4N HC1 (4 mL) and 1, 4-dioxane (4 mL) at 50C for 3h. Concentration provided 3-(5-morpholino-3-(quinolin-3-yl)pyrazolo[lf5-a]pyrimidin-7-ylamino)propanoic acid. LCMS tR = 1.30 Min (5 min run, UV 2s4nm)- Mass calculated for, M+ 18.1, observed LC/MS m/z 419.2 (M+H).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; SCHERING CORPORATION; MENG, Zhaoyang; REDDY, Panduranga Adulla, P.; SIDDIQUI, M. Arshad; MANDAL, Amit, K.; LIU, Duan; ZHAO, Lianyun; MCRINER, Andrew; WO2012/27234; (2012); A1;,
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