Month: July 2021

Synthetic Route of 99548-55-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 99548-55-7, name is Methyl 4-bromo-2-methylbenzoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Step 2. To a solution of 28 (1.0 g, 4.37 mmol) and NBS (0.93 g, 5.24 mmol) in CC14 (10 mL) was added BPO (106 mg, 0.44.00 mmol). The reaction mixture was stirred at 80C for 5 h. Upon completion, the reaction was quenched with H20 (10 mL) and extracted with ethyl acetate (3 x 20 mL). The the organic layer was washed with H20 (3 x 10 mL), concentrated, and purified by prep-TLC (petroleum : ethyl acetate = 20: 1) to afford 29 (610 mg, 41%).

The synthetic route of Methyl 4-bromo-2-methylbenzoate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NUMERATE, INC.; RAIMUNDO, Brian; KOLTUN, Elena S.; GRIFFIN, John; STANGELAND, Eric; (50 pag.)WO2018/49328; (2018); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 27492-84-8, name is Methyl 4-amino-2-methoxybenzoate, A new synthetic method of this compound is introduced below., Quality Control of Methyl 4-amino-2-methoxybenzoate

Method 2A mixture of methyl 4-amino-2-methoxybenzoate (10.8 g, 59.6 mmol), the product from step(i) above (20.09 g, 54.2 mmol) and potassium carbonate (15 g, 109 mmol) in DMF (300 mL)was degassed with N2 for 10 mm. BrettPhos G3 precatalyst(1 g, 1.103 mmol) was added andthe mixture heated at 85°C for 3 h. The mixture was cooled then partitioned between DCM(500 mL) and water (800 mL). The organic layer was washed with water (500 mL), dried (MgSO4), filtered and evaporated under reduced pressure. The residue was triturated with ether, filtered and dried to afford the sub-title compound (21.7 g) as a grey solid. 1H NMR (400 MHz, DMSO-d6) O 9.38 (s, IH), 9.36 (s, IH), 8.18 (d, IH), 8.14 (d, IH), 7.83 (d,IH), 7.54-7.66 (m, 5H), 7.38 (d, IH), 7.22 (dd, IH), 6.69 (dd, IH), 6.14 (d, IH), 3.74 (s, 3H),3.71 (s, 3H), 1.53 (s, 9H).LCMS m/z 516 (M+H) (ES)

The synthetic route of 27492-84-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED; FYFE, Matthew Colin Thor; (62 pag.)WO2016/51188; (2016); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

These common heterocyclic compound, 99548-54-6, name is Methyl 3-bromo-2-methylbenzoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 99548-54-6

To a round-bottomed flask, methyl 3-bromo-2-methylbenzoate (18.3 g, 80 mmol, 1.0 eq), N-bromosuccinimide (17.1 g, 96 mmol, 1.2 eq) and benzoyl peroxide (1.9 g,8.0 mmol, 0.1 eq) were mixed in 150 mL of benzene. The reaction mixture was stirred at 80 C for 12 h. After cooling to room temperature, the reaction mixture was evaporated to remove most of the solvent. The resulting residue was purified by flash column chromatography with hexane/ethyl acetate to give the desired product Si as colorless oil (23.4 g, 95% yield).

The synthetic route of Methyl 3-bromo-2-methylbenzoate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; THE REGENTS OF THE UNIVERSITY OF MICHIGAN; WANG, Shaomeng; HU, Yang; QIN, Chong; XU, Fuming; HU, Jiantao; XIANG, Weiguo; ZHOU, Bing; (233 pag.)WO2018/52949; (2018); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Related Products of 455-68-5,Some common heterocyclic compound, 455-68-5, name is Methyl 3-fluorobenzoate, molecular formula is C8H7FO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Different substituted carboxylic acids (20 mmol) (A) were stirred with thionyl chloride (100 mmol) in dry methanol (75 ml) or 5?6 h to synthesize corresponding methyl esters (B) (Scheme1). After extraction of esters in chloroform, solvent was evaporated and esters (66 mmol) were refluxed with hydrazine hydrate(330 mmol) in ethanol (75 ml) for 4?5 h. A solid was obtained upon removal of the solvent by rotary evaporation. The resulting solid was washed with hexane to afford hydrazide ligand (C). The spectral and analytical data are given below.

The synthetic route of 455-68-5 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Ain, Qurrat Ul; Ashiq, Uzma; Jamal, Rifat Ara; Mahrooof-Tahir, Mohammad; Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy; vol. 115; (2013); p. 683 – 689;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 82782-85-2, name is Methyl 4H-thieno[3,2-b]pyrrole-5-carboxylate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 82782-85-2, category: esters-buliding-blocks

2.5. Synthesis of methyl 2-methyl-4H-furo[3,2-b]pyrrole-5-carboxylate Under N2, to 9 mL of glacial acetic acid were added N,N-dimethylamine (40% aqueous solution) (437 mg, 9.94 mmol), formaldehyde (37% aqueous solution) (283 mg, 9.90 mmol), and methyl 4H-thieno[3,2-b]pyrrole-5-carboxylate (1.64 g, 9.94 mmol). The temperature was kept between 0 and 5 C. while the components were added. The reaction mixture was heated at reflux for 1 h, and was then allowed to stand at rt for 12 h. The mixture was poured onto 30 g of ice, and it was brought to pH 10 by careful addition of 10% sodium hydroxide. The temperature was not allowed to exceed 10 C. while the base was added. The gummy substance solidified when stored in the refrigerator overnight. The solid was collected and dried in vacuo. It was recrystallized from petroleum ether (30-60 C.) to yield methyl 2-[(dimethylamino)methyl]-4H-furo[3,2-b]pyrrole-5-carboxylate (0.80 g, 36%). 1H NMR (400 MHz, CDCl3) delta ppm 2.36 (s, 6H) 3.71 (s, 2H) 3.81 (s, 3H) 6.33 (s, 1H) 6.69 (s, 1H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 4H-thieno[3,2-b]pyrrole-5-carboxylate, and friends who are interested can also refer to it.

Reference:
Patent; SEPRACOR INC.; US2008/4327; (2008); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 52273-79-7, name is Ethyl 2-(3-aminophenyl)acetate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 52273-79-7, COA of Formula: C10H13NO2

Ethyl 3-{3-[N-(3-methoxyphenyl)-N-(N-methyl-N-phenylcarbamoylmethyl)carbamoylmethyl]ureido}phenylacetate may be prepared in a manner similar to that described in Example 26 for the preparation of ethyl 3-{3-[N-(3-methoxyphenyl)-N-(N-methyl-N-phenylcarbamoylmethyl)carbamoylmethyl]ureido}benzoate, but starting with 2-[N-(3-methoxyphenyl)isocyanatoacetamido]-N-methyl-N-phenylacetamide (2.4 g) and ethyl 3-aminophenylacetate (1.1 g). The crude product is purified by chromatography on silica (0.063-0.2 mm) (60 g) contained in a column 2.0 cm in diameter [eluent: dichloromethane/ethyl acetate (20:80 by volume)], collecting 20-cc fractions.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 2-(3-aminophenyl)acetate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Rhone-Poulenc Rorer S.A.; US5475106; (1995); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 40876-98-0, name is Sodium 1,4-diethoxy-1,4-dioxobut-2-en-2-olate, A new synthetic method of this compound is introduced below., Recommanded Product: Sodium 1,4-diethoxy-1,4-dioxobut-2-en-2-olate

A solution of sodium hydroxide (2.85 g, 71.3 mmol) in water (3 ml) was added to a stirred solution of diethyl oxaloacetate sodium salt (8.7 g, 50 mmol) in water (50 ml) and the mixture stirred for 20 minutes. Cyclopropylcarboxamidine hydrochloride salt (5.0 g, 40 mmol) was added to the solution and the mixture was heated at 70 0C overnight, then cooled to ambient temperature and acidified to pH1 by the cautious addition of concentrated hydrochloric acid. The precipitate was isolated by filtration and dried to yield 2-cyclopropyl-4-hydroxypyrimidine-6-carboxylic acid (4.7 g, 63%). Characterising data for the compound are as follows: 1H nmr (400MHz, d6-DMSO) deltaH 13.30 (1H, br s), 12.97 (1H, br s), 6.59 (1H, s), 1.94 (1H, quintet), 1.04 (4H, m) ppm.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; SYNGENTA LIMITED; WO2009/81112; (2009); A2;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthetic Route of 1150566-27-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1150566-27-0, name is Ethyl 6-chloroimidazo[1,2-b]pyridazine-3-carboxylate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Ethyl 6-chloroimidazo[1,2-b]pyridazine-3-carboxylate (600 mg, 2.66 mmol) and 2-(trifluoromethyl)pyrrolidine (1g, 7.19 mmol) were heated in a sealed tube at 173 C for 16h. After cooling to room temperature, water (100 mL) was added. The aqueous layer was extracted with ethyl acetate (2 x 100 mL). Combined organic layers were dried, concentrated and product was purified by column chromatography to afford ethyl 6-(2-(trifluoromethyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazine-3-carboxylate (270 mg, 30%). MS (ESI) calcd for C14H15F3N4O2 (m/z): 328.1.

The synthetic route of Ethyl 6-chloroimidazo[1,2-b]pyridazine-3-carboxylate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GlaxoSmithKline LLC; CASAUBON, Rebecca, L.; NARAYAN, Radha; OALMANN, Christopher; VU, Chi, B.; (583 pag.)EP2768509; (2017); B1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 110661-91-1, name is tert-Butyl 4-bromobutanoate, A new synthetic method of this compound is introduced below., Quality Control of tert-Butyl 4-bromobutanoate

To a solution of 3-mercapto-5-trifluoromethyl-benzoic acid methyl ester (990 mg, 4.19 mmol) in acetonitrile (25 mL) were added N,N-diisopropylethylamine (1.08 g, 1.46 mL, 8.38 mmol) and tert-butyl 4-bromobutanoate (935 mg, 4.19 mmol, CAS R 110611-91-1). The clear yellow solution was stirred at room temperature for 2.5 hours and then poured on water and ethyl acetate and the layers were separated. The aqueos layer was extracted twice with ethyl acetate. The organic layers were washed with brine, dried over magnesium sulfate, filtered, treated with silica gel and evaporated. The compound was purified by silica gel chromatography on a 50 g column using a MPLC system (CombiFlash Companion, Isco Inc.) eluting with a gradient of n- heptane : ethyl acetate (100 : 0 to 70 : 30). Light yellow liquid (1.27 g, 80%). MS (ESI+): m/z = 379 ([M+]).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; DEHMLOW, Henrietta; ERICKSON, Shawn David; MATTEI, Patrizio; RICHTER, Hans; WO2013/149977; (2013); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 13831-03-3, name is tert-Butyl propiolate, A new synthetic method of this compound is introduced below., SDS of cas: 13831-03-3

(1.0 mmol) of 1- (4′-bromophenyl) -2,2,2-trifluoroethanone (1.0 mmol), t-butyl propiolate (1.0 mmol),t-butylpropiolateAg2CO3(0.05 mmol), KOH (0.1 mmol) and DMA (1 mL) were added to Xu Linke bottles and thereaction was stirredatroom temperature for 24 h. The reaction was followed by TLC.After completion of the reaction, 15 mL of saturated brine was added to quench the reaction, antishall reaction mixture was extracted with dichloromethane (15 mL × 3) the product, the organic phases were combined, and concentrated using a rotary evaporator to give crude productproduct column chromatography to obtain the target The product, eluting with column chromatography, was petroleum ether: ethyl acetate (100: 1) and the product structure wasidentifiedbyNMR and high resolution mass spectrometry.1l isolated yield of 44%, 2l isolated yield of 43%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Shihezi University; Liu Ning; Dai Bin; Wang Lei; (8 pag.)CN106432171; (2017); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics