Reference of 5445-17-0, These common heterocyclic compound, 5445-17-0, name is Methyl 2-bromopropanoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a dry 10 mL schlenk flask was added 72.0 mg (0.4 mmol) of 1,1-diphenylethylene,Methyl-2-bromopropionate (99.6 mg, 0.6 mmol)Silver oxide (9.3 mg, 0.04 mmol)Tert-butyl peroxide 72.0 mg (0.8 mmol)Triethylamine 80.8 mg (0.8 mmol)N, N-dimethylacetamide (2 mL),The reaction flask was stirred at 80 C for 24 h under argon atmosphere.After the reaction is complete,The reaction solution was washed with saturated brine,Ethyl acetate extraction (3 x 10 mL),Collecting organic phase,And dried over anhydrous magnesium sulfate.The organic solvent was removed by rotary evaporation,The residue was purified by silica gel column chromatography (petroleum ether / ethyl acetate)To give the title product (2-methyl-4,4-diphenylbut-3-enoic acid methyl ester)Yellow oily liquid,Yield 92%.
Statistics shows that Methyl 2-bromopropanoate is playing an increasingly important role. we look forward to future research findings about 5445-17-0.
Reference:
Patent; Ningbo University; Huang Huiyan; Wei Wenting; Zhu Wenming; Ying Weiwei; Zhao Chuanli; Yang Chenguang; Chen Weidong; (6 pag.)CN106892818; (2017); A;,
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