In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 18358-63-9, name is Methyl 4-(methylamino)benzoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Safety of Methyl 4-(methylamino)benzoate
The compound (3.1 g, 18.6 mmol) obtained in Step 4 above was dissolved in THF (37 mL). A solution prepared by dissolving LiAlH4 in THF (9.3 mL, 18.6 mmol) was slowly added thereto at 0 C. The resulting mixture was stirred for 8 hrs at 0 C, and an aqueous solution of Na2S04 was added to complete the reaction. Subsequently, a saturated aqueous solution of HC1 (50 mL) was added thereto, and the resulting mixture was stirred for 1 hr to form two different layers. The aqueous layer was extracted with EtOAc, and the organic layer was dried over Na2S04, distilled under reduced pressure, and purified by column chromatography (EtOAc/Hexane = 1/1 (v/v)) to obtain the title compound (1.4 g, 54%). 1H NMR (CDC13, 400 MHz) delta 7.21 (d, 2H), 6.61 (d, 2H), 4.56 (s, 2H), 2.85 (s, 3H)
The synthetic route of 18358-63-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY; KIM, Dong Jin; YOO, Kyung Ho; KIM, Young Soo; PARK, Woong Seo; KANG, Yong Koo; KIM, Hye Yun; KIM, Yun Kyung; PARK, Ki Duk; KIM, Maeng Sup; SUH, Kwee Hyun; AHN, Young Gil; WO2013/147568; (2013); A1;,
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