Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 924-99-2, name is Ethyl 3-(dimethylamino)acrylate, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of Ethyl 3-(dimethylamino)acrylate
[1353] to a mixture of ethyl 3-(dimethylamino)acrylate (92 mg, 639 umol), tea (129 mg, 1.28 mmol) in THF (10 ml) was added a solution of compound 288b (200 mg, 1.28 mmol) in THF (10 ml) over a period of 20 min. The mixture was stirred at 20 C and stirred for 12 hours. The reaction mixture was concentrated. The residue was purified by preparatory- tlc (SiO2, petroleum ether: ethyl acetate = 1 : 1) to give compound 288c (150 mg, yield: 53.8%) as yellow oil. 1H NMR (400mhz, CDCl3) delta 9.02 – 8.97 (m, 1h), 8.75 (d, = 4.6 hz, 1h), 7.87 – 7.76 (m, 2h), 7.45 – 7.36 (m, 1h), 4.27 (q, j = 7.3 hz, 2h), 1.26 (t, j = 7.2 hz, 3h).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 924-99-2.
Reference:
Patent; BLADE THERAPEUTICS, INC.; BUCKMAN, Brad, Owen; YUAN, Shendong; ADLER, Marc; EMAYAN, Kumaraswamy; MA, Jingyuang; (687 pag.)WO2018/64119; (2018); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics