Application of 36692-49-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 36692-49-6, name is Methyl 3,4-diaminobenzoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Step 1. Methyl 4-AMINO-3- (4-METHOXYBENZAMIDO) benzoate (107); [0287] A solution of 4-methoxybenzoyl chloride (1.03 g, 6.02 MMOL) in CH3CN (6 ml) was added drop wise to a solution of methyl 3, 4diaminobenzoate (106) (1.00 g, 6.02 mmol) and pyridine (0.49 ML, 6.02 MMOL) in CH3CN (25 ml) at 0C. The reaction mixture was stirred for 3 h at 0C and the solvent was evaporated. Ethyl acetate was added and the organic layer was washed successively with saturated solutions of NH4CI, NAHC03 and NACI, dried over MGS04, filtered and concentrated. After purification by flash chromatography on silica gel (eluent 1-3% MeOH in DCM), 1.03 g (56%) of compound 107 was obtained as a off white SOLID. H NMR: (DMSO) 8 (ppm): 9.51 (s, 1H), 7.96 (d, J = 8.8 Hz, 2H), 7.75 (d, J = 2.0 Hz, 1H), 7.56 (dd, J = 8.4, 2.0 Hz, 1H), 7.03 (d, J = 9.0 Hz, 2H), 6.75 (d, J = 8.4 Hz, 1H), 5.80 (s, 2H), 3.83 (s, 3H), 3.75 (s, 3H). MS: (CALC.) 300.1 ; (obt. ) 301.1 (MH) +.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 3,4-diaminobenzoate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; METHYLGENE, INC.; WO2005/30704; (2005); A1;,
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