Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 57486-67-6, name is Methyl 2-(2-fluorophenyl)acetate, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of Methyl 2-(2-fluorophenyl)acetate
Place a 100 mL two-mouth reaction bottle in an ice bath at 0 C.Add methyl orthofluorophenylacetate 2b (10.0 mmol) and 20 mL of acetonitrile.Add p-toluenesulfonyl azide 3a (11.0 mmol),1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) (15.0 mmol) was slowly added.Stir in an ice bath for 5 minutes, put into a microwave reactor, set the power 700W,The heating temperature was 60 C, the heating time was 30 min, and the exhaust fan was turned on.After the reaction is completed, the mixture is cooled to room temperature, quenched by the addition of ammonium chloride solution, and extracted with dichloromethane and water. The organic phase is collected, dried over anhydrous sodium sulfate, filtered, and evaporated. Chromatography (eluent: petroleum ether (60-90 C) / ethyl acetate, v/v = 80:1) afforded the title product 1b (1.55 g, yield: 85%). The target product was confirmed by nuclear magnetic resonance spectroscopy and high resolution mass spectrometry.
According to the analysis of related databases, 57486-67-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Nanjing Tech University; Gao Zhen; Yi Xiangyan; Huang Fei; Huang He; Yu Yang; Zhang Zhipeng; Xue Lian; Wang Lize; Qiao Nasen; (12 pag.)CN108727216; (2018); A;,
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