Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 98545-64-3, name is Methyl 4-amino-2-bromobenzoate, A new synthetic method of this compound is introduced below., name: Methyl 4-amino-2-bromobenzoate
To a solution of 4-amino-2-bromobenzoic acid methyl ester (1700 mg, 7.368 mmol) in concentrated hydrochloric acid (27 mL) and water (102 mL) was added dropwise a solution of sodium nitrite (567 mg, 8.104 mmol) in water (25 mL) at -5C, and the mixture was stirred at -5C for 30 minutes. To the reaction mixture was added dropwise a solution prepared in (1-A) at -5C, the reaction temperature was gradually elevated, and the mixture was stirred at room temperature for 2 hours. The obtained viscous material was collected by filtration, the obtained viscous material was dissolved in chloroform, dried, and concentrated under reduced pressure. The obtained residue was purified by a silica gel column chromatography (hexane:ethyl acetate = 100:0?60:40) to give methyl 2-bromo-4-(chlorosulfonyl)benzoate (997 mg, 43%) as an orange solid. 1H-NMR (DMSO-d6) delta 3.86 (3H, s), 7.66 (1H, dd, J = 1.5 Hz, 7.9 Hz), 7.76 (1H, d, J = 7.9 Hz), 7.84 (1H, d, J = 1.5 Hz).
The synthetic route of 98545-64-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Mitsubishi Tanabe Pharma Corporation; KATO, Taku; SAKAMOTO, Toshiaki; KUBO, Akira; SAWAMOTO, Daisuke; EP2896613; (2015); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics