Synthetic Route of 148547-19-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 148547-19-7, name is Methyl 4-bromo-3-methylbenzoate, This compound has unique chemical properties. The synthetic route is as follows.
Synthetic Route of 148547-19-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 148547-19-7, name is Methyl 4-bromo-3-methylbenzoate, This compound has unique chemical properties. The synthetic route is as follows.
A roundbottom flask was charged with methyl 4-bromo-3-methylbenzoate (200 mg, 0.878 mmol), bis(pinacolato)diboron (277 mg, 1.089 mmol), PdCl2(dppf)CH2Cl2 (70 mg, 0.0873 mmol), KOAc (171 mg, 1.75 mmol), and DMSO (10 mL). The reaction was degassed with N2 and heated at 400C for 1 h, 60 0C for 1 h, and then 80 0C for 12 h. The reaction was diluted with EtOAc (25 mL) and hexanes (75 mL) and the organics were washed with water (2 x 25 mL) and brine (50 mL). The organic layer was dried (Na2SO,)), filtered, and concentrated. Purification of the residue by flash chromatography on silica gel (0 to 15% EtOAc/hexanes) afforded methyl 3-meth.yl-4-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2- yl)benzoate. 1H NMR (500 MHz, CDCl3): delta 7.82 (s, IH)7 7.80 (s, 2H), 3.91 (s, 3H), 2.57 (s, 3H), 1.35 (s, 12H).
The chemical industry reduces the impact on the environment during synthesis Methyl 4-bromo-3-methylbenzoate. I believe this compound will play a more active role in future production and life.
Reference:
Patent; MERCK & CO., INC.; WO2007/81569; (2007); A2;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics