Application of 57381-59-6,Some common heterocyclic compound, 57381-59-6, name is Methyl 5-bromo-2-fluorobenzoate, molecular formula is C8H6BrFO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step 1 (0342) To a solution of 4a (28 g, 113 mmol) in DMF (500 mL) was added naphthalene- 1,6-diol (22 g, 136 mmol) and CS2CO3 (74 g, 226 mmol). The resulting solution was stirred at 100C for 12 h, before it was poured into water and extracted with EA. The combined organic phases were dried over Na2S04. After filtration and concentration, the residue was purified by Si02 chromatography, eluting with petroleum ether: ethyl acetate (100/1-10/1) to give compound 4b (25 g, 59.5%).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 5-bromo-2-fluorobenzoate, its application will become more common.
Reference:
Patent; MERCK SHARP & DOHME CORP.; KOZLOWSKI, Joseph, A.; YU, Wensheng; HU, Bin; ZHONG, Bin; HAO, Jinglai; WANG, Dahai; LEI, Zhixin; (82 pag.)WO2017/184476; (2017); A1;,
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