Reference of 623-47-2,Some common heterocyclic compound, 623-47-2, name is Ethyl propiolate, molecular formula is C5H6O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of ethyl propionate (A-3) (26.3 g, 0.268 mol) and AgNCb (4.56 g, 26.8 mmol) in anhydrous acetone (300 mL) was added NBS (52.6 g, 0.295 mol) in several small portions at 0 C and stirred at room temperature overnight. The mixture was filtered. The filtrate was diluted with H2O (500 mL) and extracted with n-hexane (500 mL x 3). The combined extracts were washed with an aqueous HC1 solution (10%, 500 mL x 2) and brine (500 mL), dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure at room temperature (ESI) m/z: non- ionizable compound under routine conditions used; -NMK (CDCb, 400 MHz): d (ppm) 1.32 (t, J= 7.2 Hz, 3H), 4.25 (q, J= 7.2 Hz, 2H).
The synthetic route of 623-47-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BIOMARIN PHARMACEUTICAL INC.; WANG, Bing; CHAO, Qi; (737 pag.)WO2019/133770; (2019); A2;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics