Adding a certain compound to certain chemical reactions, such as: 924-99-2, name is Ethyl 3-(dimethylamino)acrylate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 924-99-2, Product Details of 924-99-2
29.2 g of N,N dimethyl amino ethyl acrylate,20.2 g of triethylamine and 340 ml of toluene were added to the three-vial flask.Heat to 55C with stirringIt was slowly added dropwise a solution of 46.8g tetrafluorobenzoyl chloride / toluene,Add 1 hour, after the drop, keep warm for 2 hours.96% conversion, cooling,About 24.8 g of triethylamine hydrochloride was filtered.A small amount of toluene washes the triethylamine hydrochloride filter cake,The filtrate warmed to 40C.16.5 g of L-2-aminopropanol was added dropwise.After half an hour, the temperature rose to 90C.Insulation 0.5 hours, conversion 98%,Cool, wash three times, layer the toluene phase,Spin dry, add DMF diluted to 250ml,The liquid purity is 99.22%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Ethyl 3-(dimethylamino)acrylate, and friends who are interested can also refer to it.
Reference:
Patent; Taicang Datang Chemical Fiber Factory; Liu Huifeng; (9 pag.)CN107141306; (2017); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics