Introduction of a new synthetic route about 55666-43-8

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 55666-43-8, name is tert-Butyl 3-bromopropanoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. name: tert-Butyl 3-bromopropanoate

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 55666-43-8, name is tert-Butyl 3-bromopropanoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. name: tert-Butyl 3-bromopropanoate

Sodium Hydride (60% dispersion in mineral oil, 10. [1G,] 0.252 mol) was added portionwise to a stirred solution of [2-OXAZOLIDINONE] (20g, 0.23 mol) in dry tetrahydrofuran [(250ML)] at 0 [C] under nitrogen. After stirring for 30 minutes tert-butyl bromoacetate (50.8 [MI,] 0. [344MOL)] was added slowly and the reaction mixture was left heating to room temperature and stirred overnight. Water was then slowly added followed by ethyl acetate [(250ML).] The aqueous phase was extracted and washed with ethyl acetate [(50ML).] The combined organic phases were washed with brine [(200ML),] dried over magnesium sulphate and concentrated under vacuum. The title compound crystallized on standing as a white solid (45g, 97%). ‘H-NMR (400 MHz, [CDC13)] : [8=] 1.46 (s, 9H), 3.68 (t, 2H), 3.91 (s, 2H), 4.36 (t, 2H

The synthetic route of 55666-43-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PFIZER LIMITED; PFIZER INC.; WO2004/16583; (2004); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics