Synthetic Route of 2033-24-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2033-24-1, name is 2,2-Dimethyl-1,3-dioxane-4,6-dione belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
General procedure: Pyridine (2 equiv) was added to a solution of Meldrum?s acid (1 equiv) in DCM (0.7 M). The acyl chloride (1 equiv) was dissolved in DCM (1.4 M) and was added dropwise to the Meldrum?s acid solution at 0 C. The reaction was stirred for 1.5 h at 0 C and 1.5 h at room temperature. An additional portion acyl chloride (0.5 equiv) was added and stirring was continued for 12 h at room temperature. Then the reaction was stopped by adding HCl (2 M) and diluted with DCM. The organic phase was separated, dried over Na2SO4 and evaporated. The crude product was either purified by column chromatography or crystallized to yield the pure acyl Meldrum?s acid.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,2-Dimethyl-1,3-dioxane-4,6-dione, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Beyer, W.R. Christian; Woithe, Katharina; Lueke, Bettina; Schindler, Michael; Antonicek, Horst; Scherkenbeck, Juergen; Tetrahedron; vol. 67; 17; (2011); p. 3062 – 3070;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics