Related Products of 252881-74-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 252881-74-6, name is tert-Butyl 3-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)propanoate, This compound has unique chemical properties. The synthetic route is as follows.
[00229j Synthesis of N- [(PEG)3-COO-t-Buj -N?-Boc-N?-methyl-ethylene-diamine.To the solution of t-Bu-(PEG)3-amine (1 .01 g , 3.64 mmol) in 20 ml of methanol, (N-methyl)-N-Boc acetaldehyde(0.63 g, 3.64 mmol) was added. The mixture was stirred at room temperature for 3 hours. NaBH4 (0.412g, 10.9 mmol) was added to the mixture at 0C, and the resultant mixture was stirred at 0 C for 1 hour and 1 hour at room temperature. The reaction was quenched by adding 5 ml of water. After removal of solvent, 5 ml of water was added, and the mixture was extracted three times with methylene chloride. The combined organic layer was dried over Na2SO4, and the product was purified by flash silica chromatography using heptane/ethyl acetate to methylene chloride/methanol to give a yield of 72% (1.14 g). ?H NMR (300 MHz, CD2C12) oe ppm: 3.68 (t, 2H, OCH2), 3.56-3.60 (br, 1OH, CH2), 3.53 (t, 2H, OCH2), 3.29 (t, 2H, CH2), 2.85 (s, 3H, NCH3), 2.7-2.8 (m, 4H, NCH2), 2.47 (t, 2H, COCH2), 1.44 (s, 18H, CH3); MS-ESI (mle):435.5 [M+H].
The chemical industry reduces the impact on the environment during synthesis tert-Butyl 3-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)propanoate. I believe this compound will play a more active role in future production and life.
Reference:
Patent; PROMEGA CORPORATION; MUSTAFA, Dana; ZHOU, Wenhui; MEISENHERMIER, Poncho; DUELLMAN, Sarah; MA, Dongping; CALI, James, J.; WO2015/116867; (2015); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics