Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 40637-56-7, name is Dimethyl 2-allylmalonate, A new synthetic method of this compound is introduced below., Application In Synthesis of Dimethyl 2-allylmalonate
General procedure: A 50 mL Schlenk tube containing NaH (60% in mineral oil, 240 mg, 6 mmol)was evacuated and filled with argon (3x). THF (10 mL) was added and thesuspension was cooled in ice/water bath. Appropriately substituted dimethyl(allyl)malonate (5 mmol) was added dropwise (caution, hydrogen evolution),then cooling bath was removed and the reaction mixture was stirred at rt for 30min. Then substituted propargil bromide or methanesulfonate (6 mmol) wasadded and the reaction mixture was stirred at rt for 1h. The mixture wasquenched with NH4Cl(aq.) (20 mL) and extracted with MTBE (3 × 20 mL). Combined organic extractswere dried (Na2SO4), concentrated and crude product was purified by column chromatography onsilica gel (50 g column, 98:2 ? 95:5 hexanes/EtOAc).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Kocoj, Ma?gorzata; Jarosi?ska, El?bieta; Cha?adaj, Wojciech; Synlett; vol. 29; 10; (2018); p. 1319 – 1323;,
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