Reference of 59227-79-1,Some common heterocyclic compound, 59227-79-1, name is Ethyl 4-(4-chlorophenoxy)butanoate, molecular formula is C12H15ClO3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: Hydrazine hydrate (0.045 mol) was added to the solution of compounds 3a-l (0.03 mol) in ethanol (20 ml) and stirred the reaction mixture at room temperature for 5 h. Reaction completion was monitored by thin layer chromatography using hexane:ethylacetate (2:1) as the mobile phase and allowed to stand overnight. The white crystals 4a-l formed were filtered, washed and after drying recrystallized from ethanol. 4-(4-Chloro-phenoxy)-butyric acid hydrazide (4b) Yield 90%; mp 85-87 C; FT-IR (KBr, cm-1): 3315 (NH2), 3220 (NH), 1672 (C=O); 1H NMR (CDCl3): delta 2.26 (m, 2H, CH2), 2.75 (t, 2H, COCH2), 3.85 (d, 2H, NH2), 4.07 (t, 2H, OCH2), 6.88 (d, J = 8.80 Hz, 2H, Ar-H), 7.27 (d, J = 8.85 Hz, 2H, Ar-H), 8.40 (t, 1H, NH); LC-MS m/z 229 (M + 1). Anal. Calcd. for C10H13ClN2O2: C, 52.52; H, 5.73; N, 12.25. Found: C, 52.43; H, 5.75; N, 12.39%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Ethyl 4-(4-chlorophenoxy)butanoate, its application will become more common.
Reference:
Article; Al-Ghorbani, Mohammed; Vigneshwaran; Ranganatha, V. Lakshmi; Prabhakar; Khanum, Shaukath Ara; Bioorganic Chemistry; vol. 60; (2015); p. 136 – 146;,
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