Some common heterocyclic compound, 14062-29-4, name is Ethyl 2-(3-chlorophenyl)acetate, molecular formula is C10H11ClO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 14062-29-4
EXAMPLE 20 6-(3-Chlorobenzyl)-1-(2-fluorophenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one In analogy to the preparation of Example 9, 171 mg (73% of theory) of the desired product are obtained as a colourless solid starting from 0.15 g (0.66 mmol) of 5-amino-1-(2-fluorophenyl)-1H-pyrazole-4-carboxamide (Example 28A), 0.405 g (98% purity, 1.99 mmol) of ethyl (3-chlorophenyl)acetate and 0.132 g (3.32 mmol) of 60% sodium hydride. m.p.: 197 C. MS (ESI pos): m/z=355 (M+H)+ 1H-NMR (300 MHz, DMSO-d6):delta=3.95 (s, 2H), 7.2-7.7 (m, 8H), 8.3 (s, 1H), 12.5 (s, 1H) ppm.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 14062-29-4, its application will become more common.
Reference:
Patent; Bayer HealthCare AG; US2007/161662; (2007); A1;,
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