Related Products of 1462-12-0, A common heterocyclic compound, 1462-12-0, name is Diethyl 2-ethylidenemalonate, molecular formula is C9H14O4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: Isatin Schiff base 2 (22.2 mg, 0.1 mmol), the corresponding electrophile (0.2 mmol), and catalyst I (6.0 mg, 0.01 mmol) were stirred in toluene or 1,2-DCE (0.3 mL) at the reported temperature for the appropriate time (Tables 2 and 3). In the case of the reactions carried out at 2 or -25 C, the reaction vessel containing the reagents and the solvent were cooled prior to mixing together. The reactions were followed by TLC (CH2Cl2-EtOAc, 20:1). The hydrolysis was carried out in situ by adding a mixture of THF and 10% aq HCl (3:1, 1 mL) with vigorous stirring for 15-20 min. The reaction mixture was transferred to separatory funnel, diluted with H2O (10 mL), and extracted with CH2Cl2 (3 × 10 mL). The combined extracts were dried (MgSO4), concentrated, and the product was isolated by column chromatography. The racemic standards were obtained by the same procedure using 1 equiv of K2CO3 as catalyst. After the completion of the reaction, the mixture was separated from K2CO3, hydrolyzed, and purified in the same manner.
The synthetic route of 1462-12-0 has been constantly updated, and we look forward to future research findings.
Reference:
Article; ?ari, Sergei; Metsala, Andrus; Kudrjashova, Marina; Kaabel, Sandra; Jaerving, Ivar; Kanger, Tonis; Synthesis; vol. 47; 6; (2015); p. 875 – 886;,
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