Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6836-21-1, name is Ethyl 2-(7-methoxynaphthalen-1-yl)acetate, A new synthetic method of this compound is introduced below., Product Details of 6836-21-1
Reference example 3: The preparation of 7-methoxy-1-naphthaleneacetic acid 40g sodium hydroxide was dissolved in 1000ml water and 1000ml 95% ethanol was added. They were mixed. Then, 50g ethyl (7-methoxy-1-naphthyl)-acetate was added into above-mentioned mixture solution and the mixture solution was stirred for 3 hours at room temperature. The reaction was subsequently stopped and vacuum evaporated to remove ethanol, resulting in brown-red liquid. The liquid was washed with 300mlx2 ethyl acetate prior to adding 30ml 95% ethanol into the aqueous layer. The pH was adjusted to 2 by adding concentrated hydrochloric acid in drops with rapid stirring, resulting in a large amount of light brown solid being precipitated. They were filtered and dried to obtain 32g product with mp of 154-156C. The content measured by HPLC is 98.48%, and the yield is 72%.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Tianjin Taipu Pharmaceutical Science & Technology Development Co., Ltd.; EP2474522; (2012); A1;,
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