Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 106-65-0, name is Dimethyl succinate, A new synthetic method of this compound is introduced below., Safety of Dimethyl succinate
Potassium (3.10 g, 0.08 mol) andt-BuOH (110 ml) were stirred at 60 C for 3 h under nitrogen until the potassium disappeared. t-BuOH was evaporated under reduced pressure to obtain the white solid (t-BuOK). Then (3,4-dimethoxyphenyl)(phenyl)methanone (5) (15.00 g, 0.06 mol), dimethyl succinate (11.50 g, 0.07 mol), and toluene (100 ml) were added and stirred at 110 C for 34 h. After completion of the reaction, water (100 ml) was added, and the aqueous phase was extracted with toluene (3¡Á50 ml). The combined organic phases were dried over anhydrous Na2SO4, concentrated under reduced pressure, and product 6 was purified by recrystallization from n-hexane-EtOAc, 4:1. Yield 18.86 g (85 %), yellow solid,mp 211-212 C. 1H NMR spectrum, delta, ppm (J, Hz): 3.48(3H, d, J = 2.4, OCH3); 3.59 (2H, s, CH2); 3.78 (3H, s,OCH3); 3.89 (3H, s, OCH3); 6.68-6.73 (2H, m, H Ar); 6.83-6.87 (1H, m, H Ar); 7.10-7.14 (2H, m, H Ar); 7.26-7.29 (3H,m, H Ar). 13C NMR spectrum, delta, ppm: 27.4; 38.4; 51.7;55.9; 81.2; 110.9; 112.5; 122.2; 123.4; 127.9; 128.8; 133.8; 141.9; 148.7; 149.3; 152.8; 169.2; 170.2; 177.2. Found, %:C 67.26; H 5.73. C20H20O6. Calculated, %: C 67.41; H 5.66
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Zhao, Qian; Yang, Yanhua; Duan, Yingxiang; Tao, Xian; Shen, YingZhong; Chemistry of Heterocyclic Compounds; vol. 54; 9; (2018); p. 840 – 847; Khim. Geterotsikl. Soedin.; vol. 54; 9; (2018); p. 840 – 847,8;,
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