Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 35179-98-7, name is Chloromethyl ethyl carbonate, A new synthetic method of this compound is introduced below., Recommanded Product: 35179-98-7
To a solution of (2S,3S)-3-((2-bromo-5-fluoro-6-(thiophen-2-yl)pyrimidin-4-yl)amino)bicyclo[2.2.2]octane-2-carboxylic acid (2.00 g, 4.69 mmol) in DMF (20 mL) wereadded potassium carbonate (2.02 g, 14.20 mmol) and chloromethyl ethyl carbonate (0.79 g, 5.70mmol), and the mixture was stirred at rt overnight. To the reaction mixture was added water (50mL), and the resulting mixture was extracted with ethyl acetate (50 mL x 3). The combinedorganic layers were washed with saturated brine (100 mL x 3), dried over anhydrous sodiumsulfate and filtered. The filtrate was concentrated in vacuo and the residue was purified by silicagel column chromatography (PE/EtOAc (v/v) = 511) to give the title compound as a light yellowsolid (0.48 g, 69 % ).MS (ESI, pos. ion) m/z: 527.7 [M+Ht;1H NMR (400 MHz, CDCb) 8 (ppm): 7.84-7.81 (m, 1H), 7.57 (d, J = 5.0 Hz, 1H), 7.20-7.14(m, 1H), 6.02 (d, J = 5.7 Hz, 1H), 5.77 (d, J = 5.6 Hz, 1H), 4.45 (d, J = 5.2 Hz, 1H), 4.24 (q, J =7.1 Hz, 2H), 2.50 (d, J = 5.4 Hz, 1H), 2.03 (d, J = 2.3 Hz, 1H), 1.91 (d, J = 2.4 Hz, 1H), 1.81 (m,1H), 1.72 (m, 4H), 1.65- 1.57 (m, 2H), 1.33 (t, J = 7.1 Hz, 3H).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; TANG, Changhua; REN, Qingyun; YIN, Junjun; YI, Kai; LEI, Yibo; WANG, Yejun; ZHANG, Yingjun; (303 pag.)WO2018/108125; (2018); A1;,
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