In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 431-47-0 as follows. Formula: C3H3F3O2
A. Preparation of N-propargyltrifluoroacetamide (43) Propargylamine (24.79 g, 0.450 mole; Aldrich, 99%) was added dropwise over 1 h to methyl trifluoroacetate (69.19 g, 0.540 mole, 1.2 eq, Aldrich) at 0. After stirring an additional hour at 0, distillation though a 15 cm Vigreux column afforded 62.12 g (91%) of trifluoroacetamide 43 as a colorless liquid (bp 68.5-69.5 at 11 torr). This material was homogeneous by NMR and GC and was used interchangeably with spectroscopically-identical material prepared by acylating propargylamine with trifluoroacetic acid anhydride. 1 H-NMR (CDCl3): 6.85 (broad s, 1H, NHTFA), 4.17 (dd, J=5.6 and 2.5, 2H, CH2), 2.35 (t, J=2.5, 1H, CH). IR (neat; cm-1): 3300 (N–H), 3095 and 2935 (C–H), 2130 (acetylene), 1720 (C=O), 1550 (N–H), 1430, 1365, 1160, 1040, 998, 918, 857, 829, 772, and 725.
According to the analysis of related databases, 431-47-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; E. I. Du Pont de Nemours and Company; US5151507; (1992); A;,
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