Electric Literature of 5445-17-0, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 5445-17-0, Name is Methyl 2-bromopropanoate, SMILES is CC(C(OC)=O)Br, belongs to esters-buliding-blocks compound. In a article, author is Ma, Yantao, introduce new discover of the category.
Synthesis and cytotoxicity of (-)-homo-renieramycin G and its derivatives
(-)-Homo-renieramycin G and its twenty derivatives were prepared from l-tyrosine methyl ester via a multi-step route. Their cytotoxicities were tested against four human cancer cell lines (A549, HeLa, KB and BGC-823). (-)-Renieramycin G and (-)-homo-renieramycin G showed comparable cytotoxicity against these four cancer cell lines, which indicated that the expansion of ring C from the six-membered 1,4-piperazinone to the seven-membered 1,4-diazepanone had no obvious impact on the cytotoxicity. Compound 42 with methyl side chain and compounds 38-41 with heterocyclic aromatic side chains at C-23 exhibited the most potent cytotoxicity with the IC50 values at the level of 10(-6) M.
Electric Literature of 5445-17-0, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 5445-17-0 is helpful to your research.