Chemistry, like all the natural sciences, SDS of cas: 623-53-0, begins with the direct observation of nature¡ª in this case, of matter.623-53-0, Name is Ethyl methyl carbonate, SMILES is O=C(OC)OCC, belongs to esters-buliding-blocks compound. In a document, author is Thorat, Raviraj Ananda, introduce the new discover.
Synthesis of Chiral-Substituted 2-Aryl-ferrocenes by the Catellani Reaction
A palladium-catalyzed and norbornene-mediated methodology has been developed for the synthesis of chiral 2-aryl-ferroceneamides from chiral 2-iodo-N,N-diisopropylferrocencarboxamide, iodoarenes, and alkenes using a JohnPhos ligand and potassium carbonate as a base in dimethylformamide at 105 degrees C. The developed three-component coupling protocol allows the compatibility of electron-withdrawing fluoro, chloro, ester, and nitro and electron-donating methyl, methoxy, dimethoxy, benzyl ether-substituted iodo-benzenes, other iodoarenes, such as iodo-naphthalene, heteroarenes, such as iodothiophene, and terminating substrates, such as methyl, ethyl, tert-butyl acrylates, and substituted styrenes with 2-iodo-N,N-diisopropylferrocencarboxamide. Furthermore, the developed three-component Catellani method proceeded with the retention of the configuration of the planar chiral ferrocene, which depends on the role of the participating carbon-iodine bond in ferrocene. Consequently, the developed protocol enabled the formation of densely substituted chiral 2-aryl ferroceneamides, exhibiting good to excellent enantioselectivity. The conversion of an ester of the synthesized chiral 2-aryl ferroceneamides has also been carried out to further accommodate the easily expendable acid and alcohol functionalities.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 623-53-0. SDS of cas: 623-53-0.