A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 39255-32-8, Name is Ethyl 2-methylpentanoate, molecular formula is C8H16O2. In an article, author is Hatano, Manabu,once mentioned of 39255-32-8, Quality Control of Ethyl 2-methylpentanoate.
Enantioselective Aza-Friedel-Crafts Reaction of Indoles and Pyrroles Catalyzed by Chiral C-1-Symmetric Bis(phosphoric Acid)
A hydrogen bonding network in chiral Bronsted acid catalysts is important for the construction of a chiral cavity and the enhancement of catalytic activity. In this regard, we developed a highly enantioselective aza-Friedel-Crafts reaction of indoles and pyrroles with acyclic a-ketimino esters in the presence of a chiral C-1-symmetric BINOL-derived bis(phosphoric acid) catalyst. The desired alkylation products with chiral quaternary carbon centers were obtained in high yields with high enantioselectivities on up to a 1.2-g scale with 0.2 mol % catalyst loading. Interestingly, the absolute configurations of the products from indoles and pyrroles were opposite even with the use of the same chiral catalyst. Moreover, preliminary mechanistic considerations disclosed that a unique hydrogen bonding network with or without pi-pi interactions among the catalyst and substrates might partially play a pivotal role.
Interested yet? Keep reading other articles of 39255-32-8, you can contact me at any time and look forward to more communication. Quality Control of Ethyl 2-methylpentanoate.