Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 55666-43-8, name is tert-Butyl 3-bromopropanoate, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 55666-43-8
Intermediate 35: tert-butyl 3-f7-famino(hvdroxyimino)methvn-3,4-dihydroisoquinolin- 2(1 hP-ylipropanoateStep 1 : tert-butyl 3-(7-cyano-3,4-dihydroisoquinolin-2(1 H)-yl)propanoate; 7-Cyano-1 ,2,3,4-tetrahydroisoquinoline (7 g; 44.25 mmol; 1 eq.) and K2CO3 (7.34 g; 53.1 mmol; 1.2 eq) were suspended in CH3CN (280 ml_). te/f-Butyl 3-bromopropionate (7.77 ml 46.46 mmol; 1.05 eq.) was added. The reaction mixture was heated to 700C for 24 hours. As the reaction was not complete, tert-butyl 3-bromopropionate (3.70 ml 22.12 mmol; 0.50 eq.) and K2CO3 (3.06 g; 22.12 mmol; 0.5 eq) were added and the mixture was stirred at 70 0C for additional 48 hours. Solvents were removed under vacuum and the solid residue was partitioned between NaHCO3 sat (100 ml.) and EtOAc (200 ml_). The organic layer was then washed with brine and dried over magnesium to give the title compound as a yellow oil (1 1.9 g; 93.9 %). It was used in the next step without further purification. 1H NMR: (DMSO-dbeta, 400MHz) delta 7.57-7.54 (m, 2H), 7.32-7.29 (m, 1 H), 3.59 (s, 2H), 2.87-2.83 (t, J = 5.94 Hz, 2H), 2.74-2.66 (m, 4H), 2.46-2.42 (t, J = 7.01 Hz, 2H), 1.39 (s, 9H). UPLC/MS: 287.1 (M+H)+. HPLC (Method A) Rt 2.37 min (Purity: 96.4 %).
According to the analysis of related databases, 55666-43-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; MERCK SERONO S.A.; QUATTROPANI, Anna; BAKER-GLENN, Charles; BLACKABY, Wesley; KNIGHT, Chris; WO2010/142628; (2010); A1;,
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