The synthetic route of Ethyl 2-amino-5-methylbenzoate has been constantly updated, and we look forward to future research findings.
These common heterocyclic compound, 58677-05-7, name is Ethyl 2-amino-5-methylbenzoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 58677-05-7
Example 51; 2-(6-(3-Methoxyphenyl)-5-methylpyridin-3-ylamino)-5-methylbenzoic acidIn a schlenck tube, a mixture of Intermediate 33 (2.55 mmol, 0.71 g), Intermediate 55 (2.57 mmol, 0.46 g), BINAP (0.25 mmol, 0.158 g), Pd2(dba)3 (0.13 mmol, 0.116 g) and NaO1Bu (6.35 mmol, 0.610 g) in toluene (20 ml) was heated at 11O0C for 12 hours, under argon atmosphere. The solvent was evaporated, the solid residue was suspended in water, the pH was taken to 6.5 and extracted with CHCI3. The crude mixture was purified by flash chromatography over SiO2 eluting with mixtures of hexane/ethyl acetate affording 0.580 g (yield 65%) of the expected compound. delta 1H NMR (300 MHz, CDCI3): 2.28 (s, 3H)1 2.34 (s, 3H), 3.85 (s, 3H), 6.95 (d, 1 H), 7.08(s, 2H), 7.23 (d, 1 H), 7.36 (t, 1H), 7.58 (s, 1 H), 7.83 (s, 1 H), 8.51 (s, 1 H).ESI/MS (m/e, %): 349 [(M+1) 100].
The synthetic route of Ethyl 2-amino-5-methylbenzoate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; LABORATORIOS ALMIRALL, S.A.; WO2009/21696; (2009); A1;,
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