Some common heterocyclic compound, 54535-22-7, name is Diethyl 2-((phenylamino)methylene)malonate, molecular formula is C14H17NO4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: Diethyl 2-((phenylamino)methylene)malonate
A mixture of aniline (1a) (9.3 g, 0.1 M) and diethyl 2-(ethoxymethylene)malonate (21.6 g, 0.1 M) was heated to 110 C. After 3 hours reaction mixture was cooled and ethanol was evaporated in vacuo to afford off-white solid which was used in next reaction without further purification.The 2-phenylaminomethylene-malonic acid diethyl ester was refluxed in Dowtherm for 15 min to 2 h. The reaction mixture was cooled to 80 C. and solid was collected by filtration and washed with hexane to yield crude ethyl 4-hydroxy-quinoline-3-carboxylate 2a which was used in next step without further purification.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 54535-22-7, its application will become more common.
Reference:
Patent; Helicon Therapeutics, Inc.; US2008/306048; (2008); A1;,
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