Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 6290-49-9, name is Methyl 2-methoxyacetate, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C4H8O3
A 10 L three-necked round bottom flask equipped with a mechanic stirrer and thermometer was charged with a solution of tert-butyl acetate (1612, 13.9 mol) in dry THF (14 L) and cooled to -70 C under N2. A solution of LiHMDS (13.9 L, 13.9 mol) in THF was added at -70 C and the mixture was allowed to stir at -70 C for 1 hour. A solution of 3b (723 g, 6.95 mol) in THF (1 L) was added to the reaction and stirred at -70 C for 0.5 hours. The reaction was quenched by the addition of water (10 L) and the mixture was extracted with EtOAc. The combined the organic phase was washed with brine, dried over Na2SO4 and concentrated in vacuo to provide 3c as oil. ?H NMR (400 MHz, CDC13) oe 4.09 (s, 2H), 3.43 (s, 2H), 3.42 (s, 2H),1.47 (s, 9H).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 6290-49-9.
Reference:
Patent; MERCK SHARP & DOHME CORP.; GRAHAM, Thomas H.; LIU, Wensheng; YU, Tao; ZHANG, Yonglian; WADDELL, Sherman T.; WAI, John S.; COLEMAN, Paul J.; SANDERS, John M.; EMBREY, Mark W.; WALJI, Abbas; FERGUSON, Ronald Dale II; MARCO, Christina Ng Di; STEELE, Thomas; HU, Lihong; PENG, Xuanjia; WO2015/89847; (2015); A1;,
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