Electric Literature of 27798-60-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 27798-60-3 name is Methyl 2-Methoxyphenylacetate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Methyl bromo-(2-methoxyphenyl)acetate; A mixture of 14.6 g (81.2 mmol) of methyl (2-methoxyphenyl)acetate, 15.2 g (85.3 mmol) of Lambda/-bromosuccinimide and a catalytic amount of AIBN in tetrachloromethane (180 ml) was heated under reflux with stirring for 2h. The cooled reaction solution was filtered, and the solvent was removed in vacuo. Yield: 21.6 g (100%) of yellow oil 1H-NMR (CDCI3): 3.78 (s, 3H), 3.87 (s, 3H), 5.90 (s, 1 H), 6.88 (d, 8.31 Hz, 1 H), 6.99 (t, 7.5 Hz, 1 H), 7.32 (dt, 7.6 Hz, 1.5 Hz, 1 H), 7.61 (dd, 7.6 Hz, 1.5 Hz). MS (API-ES,pos) m/z = 259 [M+H]+
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 2-Methoxyphenylacetate, and friends who are interested can also refer to it.
Reference:
Patent; ABBOTT GMBH & CO. KG; WO2008/25736; (2008); A1;,
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