Reference of 454-31-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 454-31-9, name is Ethyl 2,2-difluoroacetate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Intermediate 16 (3.2 g, 0.0123 mol) was stirred in toluene (150 mL) at 0C under N2. Potassium tert-butoxide (1.94 g, 17.3 mmol) was added at 0-5C, ethyldifluoroacetate (1.84 g, 0.0149 mol) was added dropwise at 0-5C. RM was stirred at RT for 2 hr. The RM was washed with 10% H2S04 in water and the OL was dried on MgS04, filtered and evaporated to yield intermediate 17 (4.16 g, 99%).
The synthetic route of Ethyl 2,2-difluoroacetate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; JANSSEN PHARMACEUTICA NV; VAN ROOSBROECK, Yves, Emiel, Maria; VAN DEN KEYBUS, Frans, Alfons, Maria; TRESADERN, Gary, John; BUIJNSTERS, Peter, Jacobus, Johannes, Antonius; VELTER, Adriana, Ingrid; JACOBY, Edgar; MACDONALD, Gregor, James; GIJSEN, Henricus, Jacobus, Maria; AHNAOU, Abdellah; DRINKENBURG, Wilhelmus, Helena, Ignatius, Maria; (216 pag.)WO2018/83098; (2018); A1;,
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