Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 18358-63-9, name is Methyl 4-(methylamino)benzoate, A new synthetic method of this compound is introduced below., SDS of cas: 18358-63-9
For example, some of the silylamines used in the examples below were prepared as follows from the free amine. (i) TMSCI, NEt3, CH2CI2, 17h (ii) a. n-BuLi, THF,-78C, 2 h. b. TMSCL, rt, 17h The silylamines where RN2 is sulfonyl were prepared as follows from a modified amine by heating with bis (trimethylsilyl) trifluoroacetamide (BSTFA). 0 R’ +, 1 MeCN, reflux RW NHTs + I R F CO 3 h, 95%-si- ti – SI- The silylamines were purified by vacuum distillation. Once purified, their were handled under nitrogen at all times, and stored at-20C
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; CAMBRIDGE UNIVERSITY TECHNICAL SERVICES LIMITED; ASTRAZENECA UK LIMITED; WO2005/90283; (2005); A1;,
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